timolol (Blocadren, Timoptic, Betimol, Istalol)

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Introduction

Tradename: Blocadren.

Indications

Contraindications

Caution:

pregnancy category = c

safety in lactation = ?

safety in lactation = -

Dosage

Timoptic (timolol maleate): 0.25% & 0.5% 5,10 & 15 mL

Istolol (timolol maleate): 0.5%

Betimol (timolol hemihydrate:) 0.25% & 0.5% 5,10 & 15 mL

Timoptic XE

  • 1 drop OU QD
  • 0.25%, 0.5%

Pharmacokinetics

elimination via liver

elimination via kidney

1/2life = 3.0-5.2 hours

protein binding = 60 %

elimination by hemodialysis = -

Adverse effects

* according to ref[11] timolol causes more orthostatic hypotension than brimonidine

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Clinical Guide to Laboratory Tests, NW Tietz (ed) 3rd ed, WB Saunders, Philadelpha 1995
  5. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  6. 6.0 6.1 Prescriber's Letter 17(3): 2010 PATIENT HANDOUT: How to Use Eyedrops COMMENTARY: Systemic Effects of Ophthalmic Beta-Blockers PATIENT HANDOUT SPANISH VERSION: Como usar las gotas para los ojos Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260309&pb=PRL (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 bacterial infections due to susceptible organisms
  8. 8.0 8.1 Wikipedia: Timolol https://en.wikipedia.org/wiki/Timolol
  9. 9.0 9.1 Cimolai N. Neuropsychiatric adverse events from topical ophthalmic timolol. Clin Med Res. 2019;17(3-4):90-96 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/31462538 PMCID: PMC6886891 Free PMC article <Internet> http://www.clinmedres.org/content/17/3-4/90
  10. 10.0 10.1 Negri L, Ferreras A, Iester M. Timolol 0.1% in glaucomatous patients: efficacy, tolerance, and quality of life. J Ophthalmol. 2019 May 2;2019:4146124 PMID: https://www.ncbi.nlm.nih.gov/pubmed/31191995 PMCID: PMC6525866 Free PMC article https://www.hindawi.com/journals/joph/2019/4146124/
  11. 11.0 11.1 11.2 NEJM Knowledge+ Ophthalmology

Database