cinacalcet (Sensipar, Mimpara)

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Introduction

Tradename: Sensipar (new 2004)

Indications

Contraindications

pregnancy category = c

Dosage

Tabs: 30, 20, 90 mg

Pharmacokinetics

elimination by hemodialysis = -

Monitor

  • serum Ca+2 prior to initiation & within 1 week of initiation or dosage adjustment
  • maintanence serum Ca+2 every 2 months

Adverse effects

Drug interactions

Mechanism of action

Notes

  • Manufacturer: Amgen
  • very expensive[5]

More general terms

References

  1. New Drug: Cinacalcet (Sensipar) Prescriber's Letter 11(4):23-24 2004 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=200412&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. 2.0 2.1 Journal Watch 24(11):90, 2004 Block GA, Martin KJ, de Francisco AL, Turner SA, Avram MM, Suranyi MG, Hercz G, Cunningham J, Abu-Alfa AK, Messa P, Coyne DW, Locatelli F, Cohen RM, Evenepoel P, Moe SM, Fournier A, Braun J, McCary LC, Zani VJ, Olson KA, Drueke TB, Goodman WG. Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis. N Engl J Med. 2004 Apr 8;350(15):1516-25. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15071126
    Curhan G. Fooling the parathyroid gland--will there be health benefits? N Engl J Med. 2004 Apr 8;350(15):1565-7. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15071132
  3. 3.0 3.1 FDA MedWatch. Feb 26, 2013 Sensipar (Cinacalcet Hydrochloride): Drug Safety Communication - FDA Suspends Pediatric Clinical Trials After Report Of Death http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm341255.htm
  4. Lexi-Comp
  5. 5.0 5.1 5.2 Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012
  6. 6.0 6.1 NEJM Knowledge+ Question of the Week June 13, 2017 https://knowledgeplus.nejm.org/question-of-week/1011/

Database