chlorpropamide (Diabinese)

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Introduction

Tradename: Diabinese. 1st generation sulfonylurea.

Dosage

start with 100-250 mg PO QD, max 750 mg/day

Tabs: 100 & 250 mg.

Pharmacokinetics

  • no significant metabolism

elimination via kidney

1/2life = 36 hours

protein binding = 60-95 %

elimination by peritoneal dialysis = -

Adverse effects

Drug interactions

Laboratory

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1995
  3. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995

Database