phenylbutazone (Butazolidin)
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Introduction
Tradename: Butazolidin.
Pharmacokinetics
- metabolized to pharmacologically active metabolites
- oxyphenbutazone (t1/2 of 72 hours)
- 2-hydroxyphenbutasone (uricosuric)
- after a single dose, glucuronidation is dominant reaction
- passive reabsorption in distal renal tubule
elimination via liver
1/2life = 50-72 hours
protein binding = 92-99 %
Adverse effects
- peptic ulcer
- hypersensitivity reactions
- ulcerative stomatitis
- hepatitis
- nephritis
- aplastic anemia
- agranulocytosis
- leukopenia
- thrombocytopenia
Drug interactions
- enhances anticoagulant effect of warfarin
- may enhance hypoglycemic effect of sulfonylureas
- may decrease concentrations of digoxin, digitoxin
- drug interaction(s) of cholinesterase inhibitors with NSAIDs
- drug interaction(s) of lithium carbonate with NSAIDs
- drug interaction(s) of NSAIDs with oral contraceptive
- drug interaction(s) of NSAIDs with SSRIs
- drug interaction(s) of NSAIDs with antidepressants
- drug interaction(s) of aspirin with NSAIDs
- drug interaction(s) of apixaban with NSAIDs
- drug interaction(s) of warfarin with NSAIDs
- drug interaction(s) of NSAIDs with beta blockers
- drug interaction(s) of NSAIDs with ARBs
- drug interaction(s) of NSAIDs with aldosterone antagonis
- drug interaction(s) of NSAIDs with glucocorticoid
- drug interaction(s) of NSAIDs, diuretics & angiotensin II receptor antagonists
- drug interaction(s) of NSAIDs, diuretics & ACE inhibitors
- drug interaction(s) of NSAIDs with ACE inhibitors
- drug interaction(s) of NSAIDs & antihypertensives
- drug interaction(s) of NSAIDs & loop diuretics
- drug interaction(s) of NSAIDs & aspirin
Laboratory
- specimen: serum, plasma (EDTA); unstable in solution
- methods: color, GLC, HPLC
- spectophotomery measures drug & metabolite
- GLC measures drug only
- HPLC measures drug, but has poor response to metabolite
- labs with Loincs