dothiepin (Prothiaden)

Introduction

Tradename: Prothiaden

Indications

• depression

Tabs: 75 mg

Pharmacokinetics

• metabolized in liver to active metabolites
  • dothiepin-S-oxide, dothiepin sulfoxide
  • northiadin
  • northiadin-S-oxide
• a single 75 mg dose leads to mean serum level of 71 ng/mL
• 1/2life 14-24 hours
• decreased clearance in the elderly

elimination via liver

Adverse effects

• dry mouth
• drowsiness
• constipation
• nausea/vomiting
• diarrhea
• dizziness
• tremor
• sweating
• insomnia
• blurred vision
• weight gain
• palpitations
• hypotension
• headache
• arrhythmias (prolongation of the QT interval ?)

• drug adverse effects of tricyclic antidepressants
• drug adverse effects of antidepressants
• drug adverse effects of psychotropic agents

Laboratory

• specimen: serum, plasma; collect at steady-state
  • dothiepin in serum/plasma
• methods: HPLC, GLC, GC-MS

More general terms

• tricyclic antidepressant (TCA)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3155
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5284550
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282426