amoxapine (Asendin)

Introduction

Tradename: Asendin.

Dosage

Start 50 mg PO BID/TID, max 300 mg/day

Tabs: 25, 50, 100, 150 mg.

Pharmacokinetics

• metabolized to active metabolite, 8-OH amoxapine

elimination via liver

1/2life = 9-14 hours

protein binding = 90 %

elimination by hemodialysis = -

Adverse effects

• tinnitus
• blurred vision
• confusion
• constipation
• urinary retention
• arrhythmias
• hypotension
• parkinsonism
• tardive dyskinesia
• neuroleptic malignant syndrome
• adverse effects which occur more frequently with amoxapine than other antidepressants
  • sexual dysfunction
  • gynecomastia
  • testicular swelling
  • severe, refractory seizures with overdose
• overdose results in prolongation of the QT interval

• drug adverse effects of tricyclic antidepressants
• drug adverse effects of antidepressants
• drug adverse effects of psychotropic agents

Laboratory

• specimen: plasma (EDTA) amoxapine in serum/plasma
• methods: HPLC
• laboratories with Loincs
  • amoxapine in specimen
    • amoxapine in hair
    • amoxapine in body fluid
      • amoxapine in gastric fluid
      • amoxapine in serum/plasma
      • amoxapine in urine

More general terms

• dibenzoxazepine
• tricyclic antidepressant (TCA)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2170