sleep deprivation; insufficient sleep syndrome
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Adverse effects
Consequences of inadequate sleep:
- habitual sleep duration of < 6 hours or > 9 hours is associated with increased mortality
- habitual sleep duration of < 6 hours is associated with increased risk of glucose intolerance & type 2 diabetes RR=2.5 < 5 hours/night, RR=1.66 < 6 hours/night[1][5]
- increased susceptibility to common cold[2][10]
- increased risk of children becoming overweight/obese[3]
- enhances brain's response to hedonic food stimuli[4], thus stimulates eating
- role in automobile accidents[7]
- role in industrial accidents[7]
- increased risk of seizures[8]
- increased risk of migraine[8]
- linked to risky behavior in adolescents[13]
- alertness & attention diminished in interns in mornings after on-call shifts[11]
- increased deposition of beta-amyloid in right hippocampus & thalamus after a single night of sleep deprivation[12]
- glymphatic clearance of beta-amyloid likely impaired with sleep deprivation[12]
- increased cardiovascular risk[7]
- increased risk for mental health disorders in college students (RR=1.2-1.2)[16]
- increased risk for dementia[17] (RR=1.25)
- adults > 50 years who sleep < 6 hours/night may be at risk for chronic diseases including diabetes mellitus, cancer, coronary artery disease, stroke, heart failure, chronic obstructive pulmonary disease, chronic kidney disease, liver disease, depression, dementia, Parkinson's disease, & arthritis[19]
- chronic sleep deprivation is associated with increased risk of systemic lupus erythematosus in women with stronger effects among women with body pain & depression[20]
Laboratory
- sleep deprivation increases CSF-tau by 50% & CSF beta-amyloid by 30%[14]
Management
- later school starting times may facilitate greater sleep duration in adolescents & improve some measures of in school mood & sleepiness[9]
- extending sleep time in overweight adults from < 6.5 hours to 8.5 hours/night decreased energy intake (270 kcal/day) without change in energy expenditure resulting in weight reduction (0.9 kg)[18]
- when a medical resident exhibits signs of sleep dperivation, the observation should be discussed with the resident & the resident should go home to rest before returning to work[21]
- naps may not provide adequate rest & recovery[21]
Comparative biology
- interrupted sleep leads to higher numbers of monocytes & larger atherosclerotic lesions in atherosclerosis-prone mice & to production of less hypocretin (orexin) in the hypothalamus[15]
- lower production of hypocretin results in higher numbers of monocytes
- higher numbers of circulating monocytes (& other leukocytes is associated with development of atherosclerosis[15]
More general terms
Additional terms
References
- ↑ 1.0 1.1 Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, Nieto FJ. Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch Intern Med. 2005 Apr 25;165(8):863-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15851636
- ↑ 2.0 2.1 Cohen S et al. Sleep habits and susceptibility to the common cold. Arch Intern Med 2009 Jan 12; 169:62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19139325
- ↑ 3.0 3.1 Carter PJ et al Longitudinal analysis of sleep in relation to BMI and body fat in children: the FLAME study BMJ 2011; 342:d2712 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21622518 <Internet> http://www.bmj.com/content/342/bmj.d2712.full
Cappuccio FP and Miller MA Is prolonged lack of sleep associated with obesity? BMJ 2011; 342:d3306 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/21622519 <Internet> http://www.bmj.com/content/342/bmj.d3306 - ↑ 4.0 4.1 Benedict C et al. Acute sleep deprivation enhances the brain's response to hedonic food stimuli: An fMRI study. J Clin Endocrinol Metab 2012 Jan 18 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22259064 <Internet> http://jcem.endojournals.org/content/early/2012/01/12/jc.2011-2759
- ↑ 5.0 5.1 Buxton OM et al. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med 2012 April 11; 4:129ra43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22496545
- ↑ Volpp KG et al Effect of a Protected Sleep Period on Hours Slept During Extended Overnight In-hospital Duty Hours Among Medical Interns. A Randomized Trial JAMA. 2012;308(21):2208-2217 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23212498 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=1475185
- ↑ 7.0 7.1 7.2 7.3 Medical Knowledge Self Assessment Program (MKSAP) 16, 18. American College of Physicians, Philadelphia 2012, 2018.
- ↑ 8.0 8.1 8.2 Journal Watch. General Medicine. Nov 26, 2013 Massachusetts Medical Society http://www.jwatch.org
Xie L et al. Sleep drives metabolite clearance from the adult brain. Science 2013 Oct 18; 342:373 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24136970 <Internet> http://www.sciencemag.org/content/342/6156/373
Herculano-Houzel S. Sleep it out. Science 2013 Oct 18; 342:316. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24136954 <Internet> http://www.sciencemag.org/content/342/6156/316 - ↑ 9.0 9.1 Boergers J et al. Later school start time is associated with improved sleep and daytime functioning in adolescents. J Dev Behav Pediatr 2014 Jan; 35:11 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24336089
- ↑ 10.0 10.1 Prather AA, Janicki-Deverts D, Hall MH, Cohen S Behaviorally Assessed Sleep and Susceptibility to the Common Cold. Sleep, 2015 38(9):1353-1359 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26118561 <Internet> http://www.journalsleep.org/ViewAbstract.aspx?pid=30153
Besedovsky L, Born J Sleep, Don't Sneeze: Longer Sleep Reduces the Risk of Catching a Cold. Sleep, Sept. 2015 38(9) <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26285007 <Internet> http://www.journalsleep.org/ViewAbstract.aspx?pid=30148 - ↑ 11.0 11.1 Basner M, Dinges DF, Shea JA et al. Sleep and alertness in medical interns and residents: An observational study on the role of extended shifts. Sleep 2017 Apr 1; 40:1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28329124 https://academic.oup.com/sleep/article-abstract/40/4/zsx027/3045870/Sleep-and-Alertness-in-Medical-Interns-and?redirectedFrom=fulltext
- ↑ 12.0 12.1 12.2 Shokri-Kojori E, Wang GJ, Wiers CE, et al beta-Amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci U S A. 2018 Apr 9 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29632177 Free Article <Internet> http://www.pnas.org/content/early/2018/03/29/1721694115.full
- ↑ 13.0 13.1 Weaver MD, Barger LK, Malone SK, Anderson LS, Klerman EB. Dose-dependent associations between sleep duration and unsafe behaviors among US high school students. JAMA Pediatr 2018 Oct 1; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30285029
- ↑ 14.0 14.1 Lucey BP, McCullough A, Landsness EC et al Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease. Sci Transl Med. 2019 Jan 9;11(474). PMID: https://www.ncbi.nlm.nih.gov/pubmed/30626715
Holth JK et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science 2019 Feb 22; 363:880. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/30679382 PMID: 30679382 <Internet> http://science.sciencemag.org/content/363/6429/880
Noble W, Spires-Jones TL. Sleep well to slow Alzheimer's progression? Science 2019 Feb 22; 363:813 <PubMed> PMID: 30679382https://onlinelibrary.wiley.com/doi/10.1002/acr.25017https://onlinelibrary.wiley.com/doi/10.1002/acr.25017 <Internet> http://science.sciencemag.org/content/363/6429/813 - ↑ 15.0 15.1 15.2 McAlpine CS, Kiss MG, Rattik S et al. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature 2019 Feb 21; 566:383. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30760925
- ↑ 16.0 16.1 Boyles S Sleep Deprivation Ups Mental Health Risk in College Kids MedPage Today. June 13, 2019. https://www.medpagetoday.com/meetingcoverage/apss/80445
Ramsey T et al Dose-response relationship between insufficient sleep and mental health symptoms in collegiate student athletes and non-athletes. SLEEP 2019; Abstact 0901. - ↑ 17.0 17.1 Rapaport L Sleep Problems Linked to Cognitive Decline and Dementia. Annals of Long-Term Care. Jan 15, 2020 Not indexed in PubMed https://www.managedhealthcareconnect.com/content/sleep-problems-linked-cognitive-decline-and-dementia
- ↑ 18.0 18.1 Tasali E, Wroblewski K, Kahn E et al. Effect of sleep extension on objectively assessed energy intake among adults with overweight in real-life settings: A randomized clinical trial. JAMA Intern Med 2022 Feb 7; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/35129580 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2788694
- ↑ 19.0 19.1 Bender E Less Than 6 Hours of Sleep a Night Linked to Serious, Chronic Illness. Medscape. Oct 21, 2022 https://www.medscape.com/viewarticle/982848
Sabia S, Dugravot A, Leger D et al Association of sleep duration at age 50, 60, and 70 years with risk of multimorbidity in the UK: 25-year follow-up of the Whitehall II cohort study. PLOS Medicine. Published: October 18, 2022 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36256607 https://doi.org/10.1371/journal.pmed.1004109 - ↑ 20.0 20.1 Choi, MY, Malspeis, S, Sparks, JA, Cui, J, Yoshida, K and Costenbader, KH. Association of sleep deprivation and the risk of developing systemic lupus erythematosus among women. Arthritis Care Res. September 12, 2022. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36094865 https://onlinelibrary.wiley.com/doi/10.1002/acr.25017
- ↑ 21.0 21.1 21.2 Olson EJ, Drage LA, Auger RR. Sleep deprivation, physician performance, and patient safety. Chest. 2009 Nov;136(5):1389-1396. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17908706