papillomavirus (HPV) DNA; high-risk HPV testing
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Indications
- diagnosis of papillomavirus infection
- recommended as adjunctive testing to cervical cytology in women > 30 years of age (see recommendations for performing Pap smears)[2]
- standalone cervical cancer screening test*
- FDA-approval April 2014[5]
- cervical cancer screening for high-risk women >= 25 years of age[7]
- repeat screening at intervals of 3 years or longer
- HPV testing associated with a lower likelihood of high-grade cervical lesions after 4 years compared with Pap smear[8]
Specimen
- cervical smears
- self-collected vaginal swabs for high-risk women[9]
- biopsies or scrapings
- anogenital tissue
- urine[6]
- store tissue at -20 degrees C or below
Management
- women who screen positive for HPV 16 or 18 should undergo colposcopy
- women who screen positive for HPV 12 other high-risk types should undergo cytology & then either colposcopy or follow-up in 12 months[7]
Notes
- over 50 recognized types
- better sensivitity (94.6% vs 55.4%) but poorer specificity (94.1% vs 96.8%) for high-grade cervical intraepithelial neoplasia than Pap smear[3]
- several different tests[3][4]
More general terms
More specific terms
- human papilloma virus 16+18 DNA in tissue
- human papilloma virus genotyping
- papilloma virus 16 DNA
- papilloma virus 18 DNA anorectal
- papilloma virus 18 DNA in cervix
Additional terms
References
- ↑ Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
- ↑ 2.0 2.1 Journal Watch 24(6):452, 2004 Wright TC Jr et al, Obstet Gynecol 103:304, 2004 PMID: https://www.ncbi.nlm.nih.gov/pubmed/14754700
- ↑ 3.0 3.1 3.2 Mayrand M-H et al, Human papilloma DNA versus Papanicolau screening tests for cervical cancer. N Engl J Med 2007, 357:1579 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17942871
- ↑ 4.0 4.1 FDA Approves Roche's HPV Test for Identifying Women at Highest Risk for Cervical Cancer, April 20, 2011 http://www.roche.com/media/media_releases/med-cor-2011-04-20.htm
- ↑ 5.0 5.1 Herman AO NEJM Journal Watch. March 14, 2014 Massachusetts Medical Society http://www.jwatch.org
FDA News Release: April 24, 2014 FDA approves first human papillomavirus test for primary cervical cancer screening. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm394773.htm - ↑ 6.0 6.1 Pathak N et al Accuracy of urinary human papillomavirus testing for presence of cervical HPV: systematic review and meta-analysis. BMJ 2014;349:g5264 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25232064 <Internet> http://www.bmj.com/content/349/bmj.g5264
- ↑ 7.0 7.1 7.2 Young K, Sadoughi S, Sofair A Interim Guidance Released on Primary High-Risk HPV Testing for Cervical Cancer. Physician's First Watch, Jan 12, 2015 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org Huh WK, Ault KA, Chelmow D et el Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance. Gynecologic Oncology. Jan 7, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25569009 <Internet> http://www.gynecologiconcology-online.net/article/S0090-8258%2814%2901577-7/fulltext
- ↑ 8.0 8.1 Ogilvie SG, van Niekerk D, Krajden M et al Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months. The HPV FOCAL Randomized Clinical Trial. JAMA. 2018;320(1):43-52 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29971397 https://jamanetwork.com/journals/jama/fullarticle/2686793
Massad LS Replacing the Pap Test With Screening Based on Human Papillomavirus Assays. JAMA. 2018;320(1):35-37 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29971379 https://jamanetwork.com/journals/jama/fullarticle/2686771 - ↑ 9.0 9.1 Arbyn M, Smith SB, Temin S et al Detecting cervical precancer and reaching underscreened women by using HPV testing on self samples: updated meta-analyses. BMJ 2018;363:k4823 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30518635 https://www.bmj.com/content/363/bmj.k4823
- ↑ 10.0 10.1 ARUP Consult: Human Papillomavirus (HPV) Testing - Cervical Cancer Screening The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/human-papillomavirus