trilaciclib (Cosela)

Indications

• chemotherapy-induced myelosuppression in small cell lung cancer

Contraindications

• pregnancy

Adverse effects

• common
  • fatigue, headache, hypocalcemia, hypokalemia, hypophosphatemia, increased serum aspartate aminotransferase, pneumonia, pneumonitis
• serious (30%)
  • hemorrhage, respiratory failure, thrombosis most common
• other
  • drug hypersensitivity
  • interstitial lung disease,

Mechanism of action

• CDK4/CDK6 inhibitor
  • reduces bone marrow suppression & risk of neutropenia

More general terms

• small inhibitory antineoplastic agent (ib drug)
• cyclin-dependent kinase inhibitor (CDKI, CDKN)