talazoparib (Talzenna)

Indications

• treatment of childhood solid tumors
• androgen-independent metastatic prostate cancer

Dosage

Tabs: 0.25 mg, 1 mg

Mechanism of action

• inhibits poly(ADP-ribose) polymerase (PARP)
• prevents PARP-mediated DNA repair of single-strand DNA breaks via the base-excision repair pathway
• enhances the accumulation of DNA strand breaks, promotes genomic instability & eventually leads to apoptosis
• PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal & recruit other proteins to repair damaged DNA & is activated by single-strand DNA breaks

More general terms

• small inhibitory antineoplastic agent (ib drug)
• PARP inhibitor

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=44819241
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=56966514