fostamatinib (Tavalisse)

Indications

• investigative treatment of
  • rheumatoid arthritis
  • immune thrombocytopenic purpura

Dosage

Tabs: 100 mg, 150 mg

Mechanism of action

• Syk kinase inhibitor
• inhibits <A135091>Syk kinase</A135091>-mediated IgG Fc gamma receptor signaling, resulting in inhibition of activation of mast cells, macrophages, & B-cells & related inflammatory responses & tissue damage

More general terms

• enzyme inhibitor
• small inhibitory antineoplastic agent (ib drug)

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=11671467
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=25008120
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24828759