abemaciclib (Verzenio)

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Indications

* high-risk, node-positive with a Ki-67 score of > 19[4]

Dosage

Tabs: 50 mg, 100 mg, 150 mg, & 200 mg

Pharmacokinetics

Adverse effects

Mechanism of action

More general terms

References

  1. Wikipedia: Abemaciclib https://en.wikipedia.org/wiki/Abemaciclib
  2. Windle ML. FDA New Drug and Biologic Approvals -- 2017 Year-in-Review Medscape - Jan 11, 2018. https://reference.medscape.com/viewarticle/890871
    U.S. Food and Drug Administration. Novel Drug Approvals for 2017. https://www.fda.gov/Drugs/DevelopmentApprovalProcess/DrugInnovation/ucm537040.htm
  3. 3.0 3.1 Dickler MN, Tolaney SM, Rugo HS et al MONARCH 1, A Phase II Study of Abemaciclib, a CDK4 and CDK6 Inhibitor, as a Single Agent, in Patients with Refractory HR+/HER2- Metastatic Breast Cancer. Clin Cancer Res. 2017 Sep 1;23(17):5218-5224. Epub 2017 May 22. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28533223
    Sledge GW Jr, Toi M, Neven P et al MONARCH 2: Abemaciclib in Combination With Fulvestrant in Women With HR+/HER2- Advanced Breast Cancer Who Had Progressed While Receiving Endocrine Therapy. J Clin Oncol. 2017 Sep 1;35(25):2875-2884. Epub 2017 Jun 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28580882
  4. 4.0 4.1 4.2 Chustecka Z New Approval in Early Breast Cancer: First Advance in 20 Years. Medscape. October 13, 2021 https://www.medscape.com/viewarticle/960784
  5. HIGHLIGHTS OF PRESCRIBING INFORMATION. VERZENIO https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208716s000lbl.pdf