olaparib (Lynparza)

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Indications

* on list of drugs to avoid for treatment of ovarian cancer[3]

# industry-sponsored study

Contraindications

Dosage

  • tablets: 100 mg, 150 mg

Adverse effects

Laboratory

Mechanism of action

Complications

More general terms

References

  1. FDA News Release. December 19, 2014 FDA approves Lynparza to treat advanced ovarian cancer First LDT companion diagnostic test also approved to identify appropriate patients http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427554.htm
  2. 2.0 2.1 Mateo J et al. DNA-repair defects and olaparib in metastatic prostate cancer. N Engl J Med 2015 Oct 29; 373:1697 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26510020 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1506859
  3. 3.0 3.1 Therapeutics Letter #108. Therapeutics Initiative Drugs to Avoid. http://www.ti.ubc.ca/2018/01/04/108-drugs-avoid/
  4. 4.0 4.1 4.2 4.3 FDA News Release. January 12, 2018 FDA approves first treatment for breast cancer with a certain inherited genetic mutation. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm592347.htm
  5. 5.0 5.1 Moore K, Colombo N, Scambia G et al Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer. N Eng J Med. Oct 21, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30345884 Free Article https://www.nejm.org/doi/full/10.1056/NEJMoa1810858
  6. Kaufman B, Shapira-Frommer R, Schmutzler RK et al Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol. 2015 Jan 20;33(3):244-50. Epub 2014 Nov 3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/25366685 Free PMC Article
  7. 7.0 7.1 de Bono J, Mateo J, Fizazi K et al. Olaparib for metastatic castration-resistant prostate cancer. N Engl J Med 2020; 382:2091-2102. May 28. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32343890 https://www.nejm.org/doi/10.1056/NEJMoa1911440
  8. 8.0 8.1 Hussain M et al. Survival with olaparib in metastatic castration-resistant prostate cancer. N Engl J Med 2020 Sep 20; [e-pub]. PMID: https://www.ncbi.nlm.nih.gov/pubmed/32955174 https://www.nejm.org/doi/10.1056/NEJMoa2022485
  9. Medscape: olaparib (Rx) https://reference.medscape.com/drug/lynparza-olaparib-999934

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