BRAF V600K mutation

Indications

• elibigiblity for treatment of metastatic melanoma with trametinib (Mekinist)

Clinical significance

• mutation present in late-stage melanomas

Procedure

• polymerase chain reaction to identify point mutation Val-600 to Lys-600 in the BRAF gene

More general terms

• BRAF V600 mutation (THxID BRAF)

Additional terms

• cutaneous melanoma
• serine/threonine protein kinase B-raf; proto-oncogene B-Raf; p94; v-Raf murine sarcoma viral oncogene homolog B1 (BRAF BRAF1 RAFB1)