homeodomain-interacting protein kinase 4 (HIPK4)

Function

• serine/threonine protein kinase
• phosphorylates human TP53 at Ser-9, & thus induces TP53 repression of BIRC5 promoter
• may act as a corepressor of transcription factors
• autophosphorylated (putative)

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, HIPK subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=2

More general terms

• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=147746
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:147746
• OMIM: https://mirror.omim.org/entry/611712
• UniProt: http://www.uniprot.org/uniprot/Q8NE63.html