nucleolar GTP-binding protein 3; guanine nucleotide-binding protein-like 3; E2-induced gene 3 protein; novel nucleolar protein 47; NNP47; nucleolar GTP-binding protein 3; nucleostemin (GNL3, E2IG3, NS)

Function

• implicated in proliferative capacity of stem cells
• may interact with p53 via basic region

Structure

• the basic domain (B) allows nucleolar localization in the absence of GTP
• the intermediate domain (I) inhibits nucleolar localization by the B domain & is required for exit from the nucleolus
  • exit from the nucleolus to the nucleoplasm requires both the I & the acidic (A) domains, & may be triggered by GTP hydrolysis (putative)
• in contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern
• belongs to the MMR1/HSR1 GTP-binding protein family
• contains 1 G (guanine nucleotide-binding) domain

Compartment

shuttles between the nucleus & nucleolus

Alternative splicing

named isoforms=2

Pathology

• may play a role in tumorigenesis
• increased expression in at least some lung cancers

More general terms

• guanine nucleotide regulatory protein (GNRP)
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26354
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26354
• OMIM: https://mirror.omim.org/entry/608011
• UniProt: http://www.uniprot.org/uniprot/Q9BVP2.html