interferon-induced guanylate-binding protein 2; guanine nucleotide-binding protein 2; GTP-binding protein 2; GBP-2; HuGBP-2 (GBP2)

Function

• binds GTP, GDP & GMP
• hydrolyzes GTP very efficiently
• GDP rather than GMP is the major reaction product

Structure

belongs to the GBP family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)

Expression

• induced by interferon gamma during macrophage activation

Notes

• distinguish from GTP-binding protein 2

More general terms

• guanine nucleotide regulatory protein (GNRP)
• prenyl protein

Additional terms

• GTP-binding protein 2 (GTPBP2)

Database

• UniProt: http://www.uniprot.org/uniprot/P32456.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2634
• OMIM: https://mirror.omim.org/entry/600412