GTP-binding protein RAD; Ras associated with diabetes; RAD1 (RRAD, RAD)

Function

• role in cardiac antiarrhythmia via strong suppression of voltage-gated L-type Ca+2 currents (putative)
• regulates voltage-dependent L-type Ca+2 channel subunit alpha-1C (CACNA1C) trafficking to the cell membrane (putative)
• inhibits cardiac hypertrophy through CaM kinase 2 pathway
• inhibits phosphorylation & activation of CAMK2D
• interacts with calmodulin preferentially in the inactive, GDP-bound form
• binds CAMK2 which is capable of phosphorylating RAD in vitr
• interacts with CAMK2D & CACNB2
• interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane

Structure

belongs to the small GTPase superfamily, RGK family

Compartment

cell membrane (putative)

Expression

• most abundantly expressed in the heart
• also found in the skeletal muscle & lung
• lesser amounts in placenta & kidney
• also detected in adipose tissue

Pathology

• overexpressed in muscle of patient with type 2 diabetes
• down-regulated in failing hearts

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6236
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6236
• OMIM: https://mirror.omim.org/entry/179503
• UniProt: http://www.uniprot.org/uniprot/P55042.html