calcium/calmodulin-dependent protein kinase II delta (CAMK2D)

Function

• one of 4 CaM-kinase 2 subunits that comprise CaM-kinase 2 complex

Structure

• belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. CaMK subfamily
• contains 1 protein kinase domain

Alternative splicing

named isoforms=9

Expression

• expressed in cardiac muscle & skeletal muscle
• isoform delta 3, isoform delta 2, isoform delta 8 & isoform delta 9 are expressed in cardiac muscle
• isoform delta 11 is expressed in skeletal muscle

Pathology

• expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy

More general terms

• protein subunit
• serine/threonine kinase
• phosphoprotein
• calmodulin binding protein

Component of

• calcium/calmodulin dependent protein kinase 2

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:817
• OMIM: https://mirror.omim.org/entry/607708
• UniProt: http://www.uniprot.org/uniprot/Q13557.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=817