GTP-binding protein GEM; GTP-binding mitogen-induced T-cell protein; RAS-like protein KIR (GEM, KIR)

Function

• could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane
• has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity
• phosphorylated on Tyr
• interacts with calmodulin in a Ca+2-dependent manner
• binds ROCK1

Structure

belongs to the small GTPase superfamily, RGK family

Compartment

• cell membrane
• peripheral membrane protein, cytoplasmic side

Expression

• most abundant in thymus, spleen, kidney, lung, & testis
• less abundant in heart, brain, liver & skeletal muscle
• induced by mitogens

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2669
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2669
• OMIM: https://mirror.omim.org/entry/600164
• UniProt: http://www.uniprot.org/uniprot/P55040.html