GTP-binding protein 10 (protein obg homolog 2, ObgH2, GTPBP10, OBGH2, UG0751c10)

Function

• role in the ribosome maturation process
• role of GTPase in vitro.
• when missing, disorganization of the nuceleolar architecture is observed

Structure

belongs to the GTP1/OBG family

Compartment

• nucleus, nucleolus
• found in the dense fibrillar compartment region of nucleolus
• at onset of mitosis, moves to chromosome surface & remains there until anaphase
• gradually re-assembles into the nucleolus at late anaphase to telophase

Alternative splicing

named isoforms=3

More general terms

• guanine nucleotide regulatory protein (GNRP)
• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/A4D1E9.html