Rho-related GTP-binding protein RhoV (Wnt-1 responsive Cdc42 homolog 2, WRCH-2, CDC42-like GTPase 2, GTP-binding protein-like 2, Rho GTPase-like protein ARHV, RHOV, ARHV, WRCH2)

Function

• plays a role in the control of the actin cytoskeleton via activation of the JNK pathway (putative)
• interacts with PAK2 (putative)

Cofactor: Mg+2 (putative)

Structure

• belongs to the small GTPase superfamily, Rho family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side (putative)
• endosome membrane; lipid-anchor; cytoplasmic side (putative)
• treatment with TNF activates endosomal but not plasma membrane RHOV (putative)

Expression

highly expressed in pancreas, placenta, & fetal brain

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1711
• UniProt: http://www.uniprot.org/uniprot/Q96L33.html