Rho-related GTP-binding protein RhoU (Wnt-1 responsive Cdc42 homolog 1, WRCH-1, Ryu GTPase, CDC42-like GTPase 1, Rho GTPase-like protein ARHU, GTP-binding protein-like 1, RHOU, ARHU, CDC42L1, G28K, WRCH1, SB128)

Function

• acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover & increase cell migration
• stimulates quiescent cells to reenter the cell cycle
• has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound
• interacts with PAK3

Cofactor: Mg+2

Structure

belongs to the small GTPase superfamily, Rho family

Compartment

• cell membrane; lipid-anchor; cytoplasmic side
• Golgi membrane; lipid-anchor
• cell junction, focal adhesion
• cell projection, podosome
• localizes to podosomes in SRC-transformed cells

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed in all tissues examined
• expressed at high levels in the stomach, small intestine, brain, skeletal muscle & placenta

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5848
• OMIM: https://mirror.omim.org/entry/606366
• UniProt: http://www.uniprot.org/uniprot/Q7L0Q8.html