GTP-binding protein REM 1; GTPase-regulating endothelial cell sprouting; Rad & Gem-like GTP-binding protein 1 (REM1, GES, REM)

Function

• endothelial cell sprouting
• actin cytoskeletal reorganization
• angiogenesis.
• Ca+2 signaling.
• interacts with calmodulin

Structure

belongs to the small GTPase superfamily, RGK family

Expression

• endothelial lining of blood vessels in uterus, heart
• lower levels found in spleen, lymph node, kidney, testis
• cells with secretory functio
  • islets of Langerhans, acinar cells in the pancreas
  • duct epithelium in the breast
  • bile duct epithelium
  • colon mucosa
  • prostate

More general terms

• cytoskeletal protein
• guanine nucleotide regulatory protein (GNRP)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=28954
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:28954
• OMIM: https://mirror.omim.org/entry/610388
• UniProt: http://www.uniprot.org/uniprot/O75628.html