Rho-related GTP-binding protein RhoJ (Tc10-like GTP-binding protein TCL, RHOJ, ARHJ, RASL7B, RHOI, TCL)

Function

• GTP-binding protein with GTPase activity
• role in formation of F-actin rich structures in fibroblasts
• regulation of cell morphology
• interacts with the CRIB domains of proteins, including Pak1 & Was/Wasp

Structure

• belongs to small GTPase superfamily, Rho family

Compartment

cell membrane, lipid-anchor

Alternative splicing

named isoforms=2

More general terms

• guanine nucleotide regulatory protein (GNRP)

Database

• OMIM: https://mirror.omim.org/entry/607653
• UniProt: http://www.uniprot.org/uniprot/Q9H4E5.html