eukaryotic peptide chain release factor GTP-binding subunit ERF3A; eukaryotic peptide chain release factor subunit 3a; eRF3a; G1 to S phase transition protein 1 homolog; G1/S transition protein 1 homolog; GTP-binding protein GST1-HS (GSPT1, ERF3A)

Function

• role in translation termination in response to the termination codons UAA, UAG & UGA
• stimulates activity of ERF1
• involved in regulation of mammalian cell growth component of the mRNA surveillance SURF complex

Structure

• belongs to the GTP-binding elongation factor family ERF3 subfamily

More general terms

• guanine nucleotide regulatory protein (GNRP)

Component of

• mRNA surveillance SURF complex

Database

• UniProt: http://www.uniprot.org/uniprot/P15170.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2935
• OMIM: https://mirror.omim.org/entry/139259