GTP-binding protein SAR1a; COPII-associated small GTPase (SAR1A, SAR1, SARA, SARA1)

Function

• role in transport from the endoplasmic reticulum to the Golgi (putative)
• required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation
• SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining ER exit sites (ERES)

Structure

belongs to the small GTPase superfamily, SAR1 family

Compartment

• endoplasmic reticulum (putative)
• Golgi apparatus (putative)

More general terms

• guanine nucleotide regulatory protein (GNRP)
• prenyl protein
• guanosine triphosphatase (GTPase)
• phosphoprotein

Additional terms

• coatomer

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56681
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56681
• OMIM: https://mirror.omim.org/entry/607691
• UniProt: http://www.uniprot.org/uniprot/Q9NR31.html