coatomer
Jump to navigation
Jump to search
Function
- one of 2 components (ARF & coatomer) necessary for assembly & budding of vesicles mediating biosynthetic transport across GOLGI stack
- binds to dilysine motifs
- reversibly associates with Golgi non-clathrin-coated vesicles
- mediates biosynthetic protein transport from endoplasmic reticulum (ER) via the Golgi to trans Golgi network
- budding from Golgi membranes
- retrograde Golgi-to-ER transport of dilysine-tagged proteins
- recruited by membranes associated with ADP-ribosylation factors
- Golgi structural integrity
- processing, activity, & endocytic recycling of LDL receptors
Structure
- protein complex of 7 distinct subunits (COPs) alpha-COP, beta-COP, beta'-COP, gamma-COP, delta-COP, epsilon-COP, zeta-COP
Compartment
- cytoplasm, Golgi
- coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
More general terms
References
- ↑ Orcl L, Palmer DJ, Amherdt M, Rothman JE. Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol. Nature. 1993 Aug 19;364(6439):732-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8355790