coatomer subunit beta; beta-coat protein; beta-COP (COPB1, COPB, MSTP026)

Function

• coatomer beta subunit
• proteolytically cleaved between Ser-528 & Ser-529 by CAPN8
• interacts with CAPN8 (putative)
• interacts with HIV-1 Nef

Compartment

• cytoplasm (putative)
• Golgi membrane
• peripheral membrane protein; cytoplasmic side
• cytoplasmic vesicle, COPI-coated vesicle membrane
• the coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on vesicles/buds originating from it
• proteolytic cleavge by CAPN8 triggers translocation from Golgi to cytoplasm (putative)
• brefeldin A induces dissociation of beta-COP from the Golgi (& presumably the other coatomer subunits)

More general terms

• coatomer protein/subunit (COP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1315
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1315
• OMIM: https://mirror.omim.org/entry/600959
• UniProt: http://www.uniprot.org/uniprot/P53618.html