protein transport protein sec16A; SEC16 homolog A (SEC16A, KIAA0310, SEC16, SEC16L)

Function

• defines endoplasmic reticulum (ER) exit sites
• required for secretory cargo traffic from the ER to the Golgi apparatus
• SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ER exit site
• required for normal transitional ER organization
• phosphorylated upon DNA damage, probably by ATM or ATR
• SEC16A & SEC16B are each present in multiple copies in a heteromeric complex
• interacts with SEC23A

Structure

belongs to the SEC16 family

Compartment

• endoplasmic reticulum membrane
• peripheral membrane
• Golgi membrane
• SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation

Alternative splicing

named isoforms=5

Expression

• ubiquitous
• expressed at higher levels in the pancreas

More general terms

• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9919
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9919
• OMIM: https://mirror.omim.org/entry/612854
• UniProt: http://www.uniprot.org/uniprot/O15027.html