Na+ dependent noradrenaline transporter; norepinephrine transporter; NET; solute carrier family 6 member 2 (SLC6A2, NAT1, NET1, SLC6A5)

Function

• amine transporter
• terminates the action of noradrenaline by its high affinity Na+-dependent reuptake into presynaptic terminals
• interacts with PRKCABP

Structure

• belongs to the Na+:neurotransmitter symporter (SNF) family

Compartment

membrane

Expression

• a 5.8 kB mRNA transcript is localized to adrenal medulla & locus ceruleus norepinephrine neurons
• a 3.6 kB mRNA transcript is ubiquitously expressed
• may be cross hybridization or glial-specific form

Pathology

• defects in SLC6A2 are a cause of orthostatic intolerance

More general terms

• solute carrier family 6
• adenosine triphosphatase (ATPase)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6530
• OMIM: https://mirror.omim.org/entry/163970
• OMIM: https://mirror.omim.org/entry/604715
• UniProt: http://www.uniprot.org/uniprot/P23975.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6530