dopamine transporter (solute carrier family 6 member 3, DA transporter, DAT, DAT1, SLC6A3)
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Function
- amine transporter
- terminates the action of dopamine by its high affinity Na+-dependent reuptake into presynaptic terminals
- interacts with PRKCABP & TGFB1I1
Structure
Compartment
membrane
Pathology
- down-regulation of dopamine transporters in part compensates for loss of dopaminergic terminals
- down-regulation is mitigated by exogenous dopamine (from levodopa, Sinemet) shorteing duration of levodopa action
Pharmacology
- SLC6A3 is the target of psychomotor stimulants such as amphetamines or cocaine
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q01959.html
- ↑ NIEHS-SNPs http://egp.gs.washington.edu/data/slc6a3/
- ↑ Wikipedia; Note: dopamine transporter entry http://en.wikipedia.org/wiki/dopamine_transporter
- ↑ Niznik HB et al The dopamine transporter is absent in parkinsonian putamen and reduced in the caudate nucleus. J Neurochem 56:192 1991 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1987318
- ↑ Giros B, Caron MG. Molecular characterization of the dopamine transporter. Trends Pharmacol Sci. 1993 Feb;14(2):43-9. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8480373
- ↑ Troiano AR et al. PET demonstrates reduced dopamine transporter expression in PD with dyskinesias. Neurology 2009 Apr 7; 72:1211. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19020294
Vingerhoets FJG. Dyskinesia in Parkinson disease: Back for the future? Neurology 2009 Apr 7; 72:1202. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19349599