GDH/6PGL endoplasmic bifunctional protein; endoplasmic bifunctional protein precursor [Includes: glucose 1-dehydrogenase, hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase] (6PGL, H6PD, G1DH)

Function

• oxidizes glucose-6-phosphate & glucose, as well as other hexose-6-phosphates

beta-D-glucose + NAD+/NADP+
          <-->
D-glucono-1,5-lactone + NADH/NADPH

D-glucose 6-phosphate + NAD+/NADP+
          <-->
D-glucono-1,5-lactone 6-phosphate + NADH/NADPH

6-phospho-D-glucono-1,5-lactone + H2O
         <-->
6-phospho-D-gluconate

Structure

• in the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family
• in the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily

Compartment

• endoplasmic reticulum lumen, microsomes

Expression

• present in most tissues
• strongest expression in liver

Pathology

• defects in H6PD are a cause of cortisone reductase deficiency

More general terms

• dehydrogenase
• glycoprotein
• human longevity protein

Additional terms

• 6-phosphogluconolactonase (6PGL, PGLS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9563
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9563
• OMIM: https://mirror.omim.org/entry/138090
• OMIM: https://mirror.omim.org/entry/604931
• UniProt: http://www.uniprot.org/uniprot/O95479.html