6-phosphogluconolactonase (6PGL, PGLS)

Function

• hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
• carbohydrate degradation, pentose phosphate pathway

Structure

• belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily

Compartment

cytoplasm (putative)

Notes

• there is also a GDH/6PGL endoplasmic bifunctional protein that contains 6-phosphogluconolactonase activity

More general terms

• hydrolase

Additional terms

• GDH/6PGL endoplasmic bifunctional protein; endoplasmic bifunctional protein precursor [Includes: glucose 1-dehydrogenase, hexose-6-phosphate dehydrogenase, 6-phosphogluconolactonase] (6PGL, H6PD, G1DH)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?
• OMIM: https://mirror.omim.org/entry/604951
• UniProt: http://www.uniprot.org/uniprot/O95336.html