kinesin family member 13B; kinesin-like protein GAKIN, guanylate kinase-associated kinesin, kinesin-like protein KIF13B (KIF13B)

Function

• may be involved in reorganization of cortical cytoskeleton
• regulates axon formation by promoting the formation of extra axons
• may be functionally important for the intracellular trafficking of MAGUKs & associated protein complexes
• binds to DLG1 & DLG4
• phosphorylated at Ser-1381 & Ser-1410 by MARK2, promoting interaction with 14-3-3 & inhibiting microtubule-dependent accumulation & formation of axons
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the kinesin-like protein family
• contains 1 CAP-gly domain
• contains 1 FHA domain
• contains 1 kinesin-motor domain

Compartment

• cytoplasm, cytoskeleton
• cell projection, axon
• accumulates at the distal part of the microtubules in the tips of axons
• does not accumulate in dendrites

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• kinesin family protein
• phosphoprotein
• human longevity protein

Database

• OMIM: https://mirror.omim.org/entry/607350
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2330
• UniProt: http://www.uniprot.org/uniprot/Q9NQT8.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23303