suppressor of cytokine signaling 2; SOCS-2; cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2 (SOCS2, CIS2, SSI2, STATI2)

Function

• regulates biological processes, including cell growth, inflammatory responses, insulin metabolism, & neuronal connections
  • involved in pathways that regulate growth hormones, growth factors, & cytokine signalling
  • role in neurological functions related to neuronal differentiation, neuronal connectivity, & neurite outgrowth
• negative regulator in the growth hormone/IGF1 signaling pathway
• probable substrate recognition component of a SCF-like ECS (elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
• protein modification; protein ubiquitination
• interacts with IGF1 receptor, prolactin receptor & growth hormone receptor
• associates with the elongin BC complex

Structure

• the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes
• contains 1 SH2 domain
• contains 1 SOCS box domain

Expression

• high expression in heart, placenta, lung, kidney & prostate
• induced by a subset of cytokines, including erythropoietin & granulocyte-macrophage colony stimulating factor (GM-CSF)

Pathology

• growth-related pathways associated with frailty

Comparative biology

• associated with phenotypes related to cell growth, body weight, bone mass, & muscle mass in animal models

More general terms

• suppressor of cytokine signaling family (SOCS family protein)
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8835
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8835
• OMIM: https://mirror.omim.org/entry/605117
• UniProt: http://www.uniprot.org/uniprot/O14508.html