suppressor of cytokine signaling 2; SOCS-2; cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2 (SOCS2, CIS2, SSI2, STATI2)
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Function
- negative regulator in the growth hormone/IGF1 signaling pathway
- probable substrate recognition component of a SCF-like ECS (elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates ubiquitination & subsequent proteasomal degradation of target proteins
- protein modification; protein ubiquitination
- interacts with IGF1 receptor, prolactin receptor & growth hormone receptor
- associates with the elongin BC complex
Structure
- the SOCS box domain mediates the interaction with the elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes
- contains 1 SH2 domain
- contains 1 SOCS box domain
Expression
- high expression in heart, placenta, lung, kidney & prostate
- induced by a subset of cytokines, including erythropoietin & granulocyte-macrophage colony stimulating factor (GM-CSF)
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O14508.html
- ↑ Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/SOCS2ID44123ch12q21.html
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8835