interleukin-12 subunit alpha; IL-12A; cytotoxic lymphocyte maturation factor 35 kD subunit; CLMF p35; IL-12 subunit p35; NK cell stimulatory factor chain 1; NKSF1 (IL12A, NKSF1)

Function

• cytokine
• can act as a growth factor for activated T-cells & NK cells, enhance lytic activity of NK/lymphokine-activated killer cells, & stimulate production of IFN-gamma by resting lymphocytes
• heterodimer with IL12B, disulfide-linked as interleukin IL-12

Structure

belongs to the IL-6 superfamily

Compartment

secreted

Pathology

• down-regulated in response to enterovirus 71 (EV71) infection

More general terms

• protein subunit
• glycoprotein
• human longevity protein

Component of

• interleukin-12; cytotoxic lymphocyte maturation factor; NK cell stimulatory factor (IL12, IL-12)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3592
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3592
• OMIM: https://mirror.omim.org/entry/161560
• UniProt: http://www.uniprot.org/uniprot/P29459.html