DNA repair protein RAD51 homolog 2; R51H2; RAD51-like protein 1; Rad51B (RAD51L1, RAD51B, REC2)

Function

• role in homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents
• may promote assembly of presynaptic RAD51 nucleoprotein filaments
• interacts with RAD51C
• the RAD51B-RAD51C dimer exhibits single-stranded DNA dependent ATPase activity
• component of BCDX2 complex
• part of a complex with RAD51C & RAD51A

Structure

• belongs to the recA family, RAD51 subfamily

Compartment

nucleus (probable)

Alternative splicing

named isoforms=5

Expression

expressed in a wide range of tissues

Pathology

• chromosomal translocation t(6;14)(p21;q23-24) involving RAD51L1 with HMGA1 is found in pulmonary chondroid hamartoma
• chromosomal translocation t(12;14)(q15;q23-24) involving RAD51L1 with HMGA2 is found in uterine leiomyoma

More general terms

• DNA repair protein Rad51 homolog
• human longevity protein

Component of

• BCDX2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5890
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5890
• OMIM: https://mirror.omim.org/entry/150699
• OMIM: https://mirror.omim.org/entry/602948
• UniProt: http://www.uniprot.org/uniprot/O15315.html