DNA repair protein RAD51 homolog 4; R51H3; RAD51-like protein 3; TRAD (RAD51L3, RAD51D)

Function

• role in homologous recombination repair pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents
• component of the BCDX2 complex
• interacts with ZSWIM7

Structure

belongs to the recA family, RAD51 subfamily

Compartment

nucleus (probable)

Alternative splicing

• named isoforms=8
• one or more isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• expressed in colon, prostate, spleen, testis, ovary, thymus & small intestine
• weakly expressed in leukocytes

Pathology

• defects in RAD51D are a cause of susceptibility to familial breast-ovarian cancer type 4

More general terms

• DNA repair protein Rad51 homolog
• human longevity protein

Component of

• BCDX2 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5892
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5892
• OMIM: https://mirror.omim.org/entry/602954
• UniProt: http://www.uniprot.org/uniprot/O75771.html