familial breast-ovarian cancer

Introduction

familial predisposition to breast cancer & ovarian cancer

Genetics

• susceptibility associated with defects in RAD51D (type 4)

Clinical manifestations

• early age of onset of breast cancer (often before age 50)
• increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently)
• frequent occurrence of breast cancer among men
• increased incidence of prostate cancer in men

More general terms

• hereditary neoplastic syndrome; cancer susceptibility syndrome

Additional terms

• breast cancer
• ovarian cancer

Database

• OMIM: https://mirror.omim.org/entry/614291