Pecanex-like protein 2 (PCNX2, PCNXL2, KIAA0435)

Structure

belongs to the pecanex family

Compartment

membrane (putative)

Alternative splicing

named isoforms=4

Pathology

• may play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H)

Genetics

• PCNXL2 is characterized by high mutational frequencies & biallelic mutations in MSI-H colorectal tumors, & is thus likely to be a target gene in these tumors

More general terms

• transmembrane 15 protein
• glycoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80003
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80003
• UniProt: http://www.uniprot.org/uniprot/A6NKB5.html