calmodulin-binding transcription activator 1 (CAMTA1, KIAA0833, MSTP023)

Function

• transcription activator
• tumor suppressor (putative)
• interacts with calmodulin (putative)

Structure

• belongs to the CAMTA family
• contains 3 ANK repeats.
• contains 1 CG-1 DNA-binding domain
• contains 1 IPT/TIG domain
• contains 3 IQ domains

Compartment

nucleus, cytoplasm

Expression

• expressed in brain (cerebellum, cortex, occipital lobe, frontal lobe, temporal lobe, putamen) heart, kidney
• expressed at low levels at interphase & in resting cells
• up-regulated during S-phase & mitosis
• levels decrease at the end of mitosis

Pathology

• expressed in cultured neuroblastoma cells
• defects in CAMTA1 associated with oligodendroglioma & astrocytoma
• a very small segment of 1p36 located within CAMTA1 is deleted in all oligodendroglial tumors with 1p LOH
  • this deletion also overlaps the neuroblastoma 1p36 deletion
• CAMTA1 shows no evidence of inactivation by somatic mutations

More general terms

• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23261
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23261
• OMIM: https://mirror.omim.org/entry/611501
• UniProt: http://www.uniprot.org/uniprot/Q9Y6Y1.html