ADAMTS-like protein 1; ADAMTSL-1; Punctin-1 (ADAMTSL1, ADAMTSR1, C9orf94, UNQ528/PRO1071)

Function

• lacks the metalloprotease & disintegrin-like domains typical of ADAMTS proteases
• O-fucosylated by POFUT2 on Ser or Thr
• fucosylated repeats can be further glycosylated by addition of a beta-1,3-glucose residue by B3GALTL
• fucosylation mediates the efficient secretion of ADAMTSL1

Structure

• C-, N- & O-glycosylated
• contains 4 Ig-like C2-type domains
• contains 1 PLAC domain
• contains 9 TSP type-1 domains

Compartment

• secreted, extracellular space, extracellular matrix

Alternative splicing

• named isoforms=6
• at least one isomer may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• expressed primarily in adult skeletal muscle

More general terms

• ADAMTS-like
• human longevity protein

Additional terms

• A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)
• ADAMTS-like protein 3 (punctin-2, ADAMTSL3, KIAA1233)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=92949
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:92949
• OMIM: https://mirror.omim.org/entry/609198
• UniProt: http://www.uniprot.org/uniprot/Q8N6G6.html