GDP-fucose protein O-fucosyltransferase 2 (peptide-O-fucosyltransferase 2, O-FucT-2, POFUT2, C21orf80, FUT13, KIAA0958)

Function

• glycosylation
• catalyzes reaction that attaches fucose through an O-glycosidic linkage to a conserved Ser or Thr in thrombospondin type-1 repeats
• transfers an alpha-L-fucosyl residue from GDP- beta-L-fucose to the Ser hydroxy group of a protein acceptor

Structure

belongs to the glycosyltransferase 68 family

Compartment

endoplasmic reticulum

Alternative splicing

named isoforms=3

Expression

• isoform A is expressed in fetal liver & peripheral blood lymphocytes
• isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver & fetal kidney
• isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver & fetal heart

More general terms

• glycosyltransferase
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y2G5.html