beta-1,3-glucosyltransferase (beta3Glc-T, beta-3-glycosyltransferase-like, B3GALTL, B3GTL)

Function

• glycosylation
• O-fucosyltransferase
• transfers glucose toward fucose with a beta-1,3 linkage
• specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thus contributing to elongation of O-fucosylglycan

Compartment

endoplasmic reticulum membrane

Expression

• widely expressed, highest levels in testis, uterus

Pathology

• defects in B3GALTL are the cause of Peters-plus syndrome

More general terms

• glycosyltransferase
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/261540
• UniProt: http://www.uniprot.org/uniprot/Q6Y288.html