Ecto-NOX disulfide-thiol exchanger 1; constitutive ecto-NOX; cNOX; candidate growth-related & time keeping constitutive hydroquinone [NADH] oxidase; cCNOX; cell proliferation-inducing gene 38 protein; [Includes: hydroquinone [NADH] oxidase; protein disulfide-thiol oxidoreductase] (ENOX1, PIG38)

Function

• probably acts as a terminal oxidase of plasma electron transport from cytosolic NADH/NADPH via hydroquinones to acceptors at the cell surface
• hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement.
• activities oscillate with a period length of 24 minutes & play a role in control of the ultradian cellular biological clock
• not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, & retinoids

Cofactor: Copper

Structure

• belongs to the ENOX family
• contains 1 RRM (RNA recognition motif) domain

Compartment

• cell membrane, secreted, extracellular space
• extracellular & plasma membrane-associated

Alternative splicing

named isoforms=2

Expression

• expressed in lymphocyte cells, breast & breast cancer (at protein level)
• found in serum of healthy volunteers or patients with disorders other than cancer

Pathology

• found in the sera of cancer patients with a wide variety of cancers including breast cancer , prostate cancer, lung cancer & ovarian cancer, leukemias, & lymphomas
• probably shed into serum by cancer cells

More general terms

• secreted protein
• oxidoreductase
• membrane protein
• RNA-binding protein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55068
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55068
• OMIM: https://mirror.omim.org/entry/610914
• UniProt: http://www.uniprot.org/uniprot/Q8TC92.html