capsaicin (Zostrix, Qutenza)

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Introduction

Tradename: Zostrix, Qutenza.

Epidemiology

  • capsaicin is the spice that make hot peppers 'hot'
  • the Carolina Reaper is one of the hottest peppers in the world[9]

Indications

* on list of medications to avoid; limited effectivness[8]

Dosage

  • apply up to QID
  • Qutenza must be applied to the skin by a healthcare professional
  • it can be used for 60 minutes, once every 3 months[5]

Cream: 0.025%, 0.075%. 45 g

Transdermal patch Qutenza: 8%

Adverse effects

Mechanism of action

Notes

  • Qutenza cost: $700/treatment (2010)

More general terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Geriatrics Review Syllabus, American Geriatrics Society, 5th edition, 2002-2004
  4. 4.0 4.1 Journal Watch 24(11):91, 2004 Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 2004 Apr 24;328(7446):991. Epub 2004 Mar 19. Review. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/15033881 <Internet> http://bmj.bmjjournals.com/cgi/content/full/328/7446/991
  5. 5.0 5.1 FDA NEWS RELEASE, Nov. 17, 2009 FDA Approves New Drug Treatment for Long-Term Pain Relief after Shingles Attacks http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm191003.htm
    Qutenza prescribing information http://www.qutenza.com/_docs/qutenza_full_PI_.pdf
  6. 6.0 6.1 Deprecated Reference
  7. Prescriber's Letter 17(5): 2010 COMMENTARY: Qutenza: A High Dose Capsaicin Patch GUIDELINES: Treatment of Postherpetic Neuralgia (QSS-ANN, 2004) GUIDELINES: Prevention of Herpes Zoster (ACIP, 2008) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=260521&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. 8.0 8.1 Therapeutics Letter #108. Therapeutics Initiative Drugs to Avoid. http://www.ti.ubc.ca/2018/01/04/108-drugs-avoid/
  9. 9.0 9.1 9.2 Deshauer S Are Spicy Foods Dangerous to Your Organs? Spicy foods may have health benefits, but they also carry some risk. MedPage Today. Oct 24, 2024 https://www.medpagetoday.com/popmedicine/popmedicine/112558

Database