complement C2; contains: complement C2b fragment; complement C2a fragment (C2)
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Function
- part of the complement classical pathway
- cleaved by activated factor C1 into 2 fragments: C2b & C2a
Structure
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
- contains 3 Sushi (CCP/SCR) domains
- contains 1 VWFA domain
Compartment
Alternative splicing
named isoforms=2
Pathology
- defects in complement C2 are the cause of complement C2 deficiency
Polymorphism
- the C2 variant Asp-318 is associated with a reduced risk of age-related macular degeneration
Notes
- complement C2 is an MHC class 3 protein
More general terms
More specific terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P06681.html
- ↑ C2base; Note: C2 mutation db http://bioinf.uta.fi/C2base/
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/c2/
- ↑ Baron M, Norman DG, Campbell ID. Protein modules. Trends Biochem Sci. 1991 Jan;16(1):13-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2053133
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=717
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:717
- OMIM: https://mirror.omim.org/entry/217000
- OMIM: https://mirror.omim.org/entry/603075
- OMIM: https://mirror.omim.org/entry/613927
- UniProt: http://www.uniprot.org/uniprot/P06681.html