acrosome formation-associated factor; equatorin (AFAF, EQTN, C9orf11)

Function

• role in acrosome biogenesis (putative)
• role in fertilization of ovum
• interacts with SNAP25

Structure

• highly N-glycosylated & O-glycosylated
• contains sialic acid

Compartment

• acrosome membrane, membrane
• cytoplasmic vesicle, secretory vesicle
• single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

• isoform 1 highly expressed in testis
• isoform 2 is expressed at low levels in skin & blood

More general terms

• membrane protein
• glycoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54586
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54586
• UniProt: http://www.uniprot.org/uniprot/Q9NQ60.html