allograft inflammatory factor 1; AIF-1; ionized Ca+2-binding adapter molecule 1; protein G1 (AIF1, G1, IBA1)

Function

• actin-binding protein
• enhances membrane ruffling & RAC activation
• enhances the actin-bundling activity of LCP1
• binds Ca+2
• role in RAC signaling & in phagocytosis
• may play a role in macrophage activation & function
• promotes proliferation of vascular smooth muscle cells & of T-cells
• enhances lymphocyte migration
• role in vascular inflammation
• phosphorylated on Ser
• homodimer (putative). monomer
• interacts with LCP1

Structure

• contains 2 EF-hand domains

Compartment

• cytoplasm, cytoskeleton, cell projection, membrane ruffle
• peripheral membrane, cytoplasmic side
• associated with the actin cytoskeleton at membrane ruffles & at sites of phagocytosis

Alternative splicing

named isoforms=3

Expression

• detected in T-cells & peripheral blood mononuclear cells

More general terms

• Ca+2 binding protein
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=199
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:199
• OMIM: https://mirror.omim.org/entry/601833
• UniProt: http://www.uniprot.org/uniprot/P55008.html